CMV & AMR in Transplant: A Focus on Graft Loss and Therapeutic Innovations

This educational activity is based on the proceedings of a symposium at the 2018 American Transplant Congress. Drs. Deepali Kumar and Alexandre Loupy present new data and challenging clinical cases in cytomegalovirus (CMV) and antibody-mediated rejection (AMR) in transplantation. You will have an opportunity to assess your skills in CMV and AMR and compare your responses to your peers when you answer interactive questions throughout the activity.

Antibody-Mediated Rejection: New Approaches in Prevention and Management

This article reviews the pathophysiology of antibody‐mediated rejection (AMR) with emphasis on the role of complement in allograft injury. It reviews the required features for a definitive diagnosis of AMR according to the latest Banff criteria, which incorporate recent findings delineating the complex spectrum of AMR and the diverse phenotypes seen. Clinical data on current and investigational treatments are summarized, and strategies to improve outcomes are presented. Lastly, a discussion of relevant predictive and surrogate endpoints provides a framework for future studies.